Monoclonal antibody higher order structure analysis by high throughput protein conformational array
نویسندگان
چکیده
منابع مشابه
High-Throughput Monoclonal Antibody Purification
the pharmaceutical ‘success story’ of the past decade. Mab-based pharmaceuticals command a worldwide market of more than $15 billion, and that figure will grow to exceed $30 billion by 2010. The proven safety and efficacy of Mabs as a drug class are driving faster developmental and regulatory timelines, and simplified routes from discovery to the clinic and from the clinic to the market. The dr...
متن کاملDevelopment of antibody arrays for monoclonal antibody Higher Order Structure analysis
Antibody arrays were developed to probe a monoclonal antibody's three-dimensional structure (3-D structure). Peptides with overlapping regions were designed to cover the whole mAb light chain and heavy chain, respectively, and used to generate polyclonal antibodies after the conjugation of the peptides to a carrier protein, KLH. It was shown that good peptide specificity was achieved from the a...
متن کاملProtein conformational space in higher order - maps
We have mapped protein conformational space from two to seven residue lengths by employing multidimensional scaling on a data matrix composed of pair-wise angular distances for multiple values collected from high-resolution protein structures. The resulting global maps show clustering of peptide conformations that reveals a dramatic reduction of conformational space as sampled by experimentally...
متن کاملHigh Throughput Monoclonal Antibody Purifi cation and Screening
Protein biologics now represent a signifi cant share of pharmaceutical research and development efforts. Their specifi city has been their key to success, as their cell-specifi c modality and relative lack of compound-specifi c toxicity have provided safer and more effective means to treat several chronic diseases. The most common class of proteins used as pharmaceuticals is monoclonal antibodi...
متن کاملHigh Throughput Method for Protein Structure Prediction
c © 2006 by John von Neumann Institute for Computing Permission to make digital or hard copies of portions of this work for personal or classroom use is granted provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise requires prior specific permission by the publisher ment...
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ژورنال
عنوان ژورنال: mAbs
سال: 2018
ISSN: 1942-0862,1942-0870
DOI: 10.1080/19420862.2017.1421880